Sharon M. Gwaltney-Brant, in Haschek and Rousseaux's Handbook of Toxicologic Pathology (Third Edition), 2013. Arsine binds to the haemoglobin of red blood cells, causing them to be destroyed by the body, resulting in haemolytic anaemia, haemoglobinuria and subsequent nephropathy with renal failure. Hemolysis in arsine-exposed RBCs depended on membrane disruption caused by arsine–hemoglobin metabolites, the ultimate toxic species (Winski et al., 1997). ARSINE is a colorless gas used in the semiconductor industry. Besides these two mechanisms, nonspecific disruption of ion gradient leading to cell membrane instability and lysis of RBCs has also been proposed as mechanism for the toxic effects of arsine (James and Woods, 2006). Treatment relies on adequate respiratory and cardiovascular support with later renal replacement therapy for renal failure. The following sections will focus on the nephrotoxicity of the major forms of inorganic arsenicals since these are of greatest public health interest. Breathing in the gas (inhalation) is the most likely route of exposure after arsine is released into the air. Trivalent arsenic is methylated to MMA and DMA (Romeo et al., 1997). Exposure to arsine in the form of Lewisite (dichloro[2-chlorovinyl] arsine) has been associated with the development of intraepidermal squamous cell carcinoma in humans; animal studies of the carcinogenicity of arsine are lacking. E. Fouquet, A. Hervé, in Comprehensive Organic Functional Group Transformations II, 2005. Figure 1. As noted above, arsenicals may exist in a number of oxidation states and as both inorganic and organic chemical species, which may undergo a number of metabolic interconversions in vivo. ; Zorin, A.D.; Zueva, M.V. Swaran J.S. Bi- and polydentate ligands containing arsenic in combination with other Group 15 or 16 donors have also been known for many years.6,7 Some new examples are shown in Figure 1. Hemolytic anemia is the most consistent clinical finding in humans. Arsine is extremely toxic and a potent hemolytic agent, ultimately causing death via renal failure. Phosphine is another chemical asphyxiant agent worthy of mention. Two mechanisms have been proposed for arsine poisoning: reaction with sulfhydryl groups (Winski et al., 1997; Waters et al., 2004) and oxidative stress (Blair et al., 1990; Hatlelid et al., 1996; Hatlelid and Carter, 1997). It is worth noting that the relative concentrations of these two oxidation states may vary depending on local redox conditions and hence it is not uncommon for both forms to be reported as present in water systems [34]. Progressive improvement in diffusing capacity of lungs was observed only after 2 months of treatment. Hamsters: Syrian Golden; 13 weeks (Inhalation) (C87001) Completed Arsine is rapidly absorbed into blood through the respiratory tract (Venugopal and Luckey, 1978). Testing Status of Arsine 11329-L . Hatlelid and Carter (1997) postulated that the hemolytic activity of arsine is related to oxidative stress through the formation of hydrogen peroxide and arsine adducts with hemoglobin. Table Showing Physical and Chemical Properties of Arsine It is used in the semiconductor and computer chip crystal manufacturing industry. It is used in making electronic components, in organic synthesis, in making lead acid storage batteries, and as a military poison gas. Arsine (AsH 3), a colourless poisonous gas composed of arsenic and hydrogen, is another familiar arsenic compound. Figure 15.2. Lowered hemoglobin levels were found in zinc ore smelting workers exposed to arsine for long periods and who had urinary arsenic concentration less than 0.2 mg/L (Watson and Griffin, 1992). High purity, submicron and nanopowder forms may be considered. Long-term exposure may cause symptoms similar to those observed in acutely poisoned individuals. It has been suggested that potassium ion channel alteration induced by arsenic may be related to hERG trafficking defects. By continuing you agree to the use of cookies. The R2AsCH2CH2PR′2 (R = tBu, Cy, R′ = Ph, iPr) have been prepared from the cyclic sulfate O2O2SOCH2CH2O⎴ treated sequentially with the appropriate lithium arsenide and phosphide, the key being to add the stronger nucleophile first, otherwise mixtures result.59 New, extremely air-sensitive arsino(phosphino)methanes R2PCH2AsR′2 (R = iPr, R′ = iPr, tBu, Cy; R, R′ = Cy) are obtained in good yield from reaction of R2PCH2SnR′3 with RLi, Me2NCH2CH2NMe2, and R′2AsCl.60, Bruce A. Fowler, in Handbook of Arsenic Toxicology, 2015. Arsine itself is odorless, it is possible to smell a slight garlic-like or fish-like scent at high concentrations. There is no specific antidote for arsine. Arsenic inhibits pyruvate dehydrogenese, uncoupling oxidation phosphorylation. Inhaled arsine was rapidly dissolved in body fluids and oxidized to As(III) (Apostoli et al., 1997). All of these chemical species of arsenic may exert nephrotoxic effects if given at sufficient dose levels or levels of exposure. he urine); jaundice; peripheral neuropathy; liquid: frostbite; [potential occupational carcinogen], Blood, kidneys, liver Cancer Site [lung & lymphatic cancer], Strong oxidizers, chlorine, nitric acid [Note: Decomposes above 446F. However, Hatlelid et al. Uses: Organic synthesis, military poison, doping agent for solid-state electronic components. After inhalation of arsine gas, it causes rapid destruction of RBCs, leading to hypoxia and renal failure. The main differences from acute poisoning were in a delay in onset and development of peripheral neuritis, development of gastrointestinal track involvement, and development of hemolysis and renal impairment. Onset of signs occurs within 30–60 min of exposure. Swaran J.S. Name : Arsine CAS No : 7784-42-1 Formula : AsH3 1.2. 305 In K = (-~H/RT) + A where K is the distribution constant for a temperature T,~H is the heat of solution of arsine in the solvent and A is a constant for . However, it is lethal in concentrations far lower than those required to produce this smell. If less than 1 hour has passed since ingestion, consider the use of activated charcoal to reduce absorption. Ventricular tachycardia and VF have been reported by St Petery et al. Symptoms usually occur within the first few hours of exposure. The gas may travel along the ground and migrate to distant ignition sources and flash back. The mechanisms underlying these effects involve occlusion of the renal tubules by hemoglobin with resulting loss of urinary output. W. Levason, G. Reid, in Comprehensive Coordination Chemistry II, 2003, Arsine AsH3, is usually made by NaBH4 reduction of AsCl3 or As2O3,16 or by hydrolysis of alkali–metal arsenides.17 Small amounts of very pure AsH3 can be obtained by heating As2O3 with LiAlH4, although the overall yield is low.18 The need for ultrapure AsH3 for CVD processes in the electronics industry and its very high toxicity has resulted in many patents dealing with on-site synthesis and purification of arsine. a colorless, flammable, slightly water-soluble gas, AsH3, having a fetid, garliclike odor, used in chemical warfare. 3.2 Chemical structure Molecular formula: AsH 3 Molecular weight: 77.93 3.3 Physical properties 3.3.1 Colour Colourless 3.3.2 State/Form Gas … Arsine (SA) is a highly toxic gas, formed by the reaction of arsenic-containing substances with hydrogen in water or acids. An alternative approach to 57 is the use of chloro derivative compound 58 in place of arsenic chloride. The storage of AsH3 as [(C6F5)3BAsH3], from which it is liberated on gentle heating has been proposed.19 Primary (AsRH2) and secondary (AsR2H) arsines have rarely been used as ligands, but can be made by reduction of the corresponding haloarsines, e.g., the preparation of Me3SiCH2AsH2 and (Me3SiCH2)2AsH,20 of arsonic or arsinic acids, e.g., AsMe2H,21 and AsBuH2,22 or by hydrolysis of metal organoarsenides, e.g., AsPh2H.23 Sterically hindered AsRH2 (R = 2,6-di-isopropylphenyl, 2,4,6-tri-isopropylphenyl) have been synthesized and characterized in detail.24, A substantial number of triorganoarsines have been prepared,7,12,13,15,25,26 although a much smaller number have been used as ligands. Arsine is extensively used in the semiconductor industry for epitaxial growth of GaAs and as a dopant for silicon-based electronic devices. Renal failure due to tubular destruction is an important consequence of arsine exposure. 2 Sb 2 O 3 + 3 LiAlH 4 → 4 SbH 3 + 1.5 Li 2 O + 1.5 Al 2 O 3. density of arsine, gas is equal to 3.186 kg/m³.In Imperial or US customary measurement system, the density is equal to 0.1989 pound per cubic foot [lb/ft³], or 0.0018416 ounce per cubic inch [oz/inch³] . Arsine is used extensively in the manufacture of microchips. Arsine is formed whenever nascent hydrogen is released in the presence of arsenic or by action of water on a metallic arsenide. Recovery from arsine poisoning will depend upon the severity and duration of exposure. (1997) detected the presence of arsenic in tissues, blood, and urine of workers in the petroleum industry who were poisoned with arsine. Arsine is the simplest compound of arsenic. Table 15.1. Arsine (AsH3) is a colorless, extremely flammable gas with a garlic-like odor. Signs and symptoms following short-term and long-term sub-lethal exposure to arsine. Arsenite (As3+) is another commonly encountered form of inorganic arsenic, and is more acutely toxic than arsenate [1,2] ostensibly as a result of complexation with the dihydrolipoic acid cofactor required for mitochondrial metabolism of NAD-linked substrate-supported mitochondrial respiration. Onset of signs occurs within 30–60 minutes of exposure. Arsine is a strong reducing agent, deposits arsenic on exposure to light and moisture, and is easily transformed into other oxidized arsenic forms (e.g., As (III) and As (V)). Arsine has some properties that may make it useful as a chemical warfare (CW) agent ; it is a colorless, odorless, nonirritating gas that is 2.5 times denser than air. The mechanism of arsine (AsH3) toxicity is not completely understood, but hemoglobin (Hb) has long been recognized as a necessary component of the overall mechanism of AsH3-induced hemolysis (Rael et al., 2006). The gas is colourless, almost odourless, and 2.5 times more dense than air, as required for a blanketing effect sought in chemical warfare. Yields vary from poor to good depending upon the R group. Possible sources of occupational exposure are many and include the semiconductor industry during microchip production and other industries in which workers are involved in galvanizing, soldering, etching, and lead plating. Arsine is supposed to be the most toxic form of arsenic. Arsine is a class of organoarsenic compounds of the formula AsH 3−x R x, where R=aryl or … Severe abdominal pain, vomiting, dyspnea, icterus, hemoglobinuria, hematuria, anemia, and death occur due to rapid intravascular hemolysis. Hepatitis in an arsine-poisoned patient on day 20 after the acute hemolysis also has been reported (Mora et al., 1992). Urinalysis typically shows large amounts of protein and free hemoglobin with only a few RBCs. - No smoking. Arsine (IUPAC name: arsane) is an inorganic compound with the formula As H 3.This flammable, pyrophoric, and highly toxic pnictogen hydride gas is one of the simplest compounds of arsenic. any derivative of this compound in which one or more hydrogen atoms are replaced by organic groups. Arsenic disrupts ATP production. Arsenic hydride; Arsenic trihydride; Arseniuretted hydrogen; Arsenous hydride; Hydrogen arsenide; Short-Term Toxicity. Arsine (AsH3) exists as a gas at room temperature and has been known for many years as a potent hemolytic agent [1–4], which produces renal failure following acute high dose exposure. P403+P233 Store in a well-ventilated place. (1970). CopyCopied, RBFQJDQYXXHULB-UHFFFAOYSA-N Arsine is generally immediately available in most volumes. How you could be exposed to arsine . It may be ingested or inhaled accidentally or deliberately. Arsine binds to hemoglobin of the red blood cells, destroying them. Trivalent arsenic is methylated to MMA and DMA (Romeo et al., 1997). It is highly flammable. 4 weeks (Inhalation) (C87001) Completed . The term arsine is commonly used to describe a class of organoarsenic compounds of the formula AsH 3−x R x, where R = aryl or alkyl. Traditional routes involve the reaction of AsX3 or AsR3−nXn (n = 1 or 2) with RMgX or RLi in ether solution. Do not induce vomiting. Common AsR3 made by this route are: AsMe3,27 AsEt3,28,29 AsnPr3,29 As(cyclo-C6H11)3,29 As(cyclo-C5H9)3,30 As(SiMe3)331 and AstBu3.31 Alkali–metal organoarsenides Li(Na)AsR2 may be reacted with R′X to form AsR2R′.32, Other organometallic reagents have been used less frequently, for example the synthesis of As(CF3)3 from Hg(CF3)2,33 or AsMe2(SMe) prepared from AsMe2Cl and Pb(SMe)2.34 More recently, AlR3 reagents have been used, which are claimed to give high yields and under appropriate conditions purer products than the Grignard or RLi routes. It is colorless and 2.5-times denser than air, with an odor resembling garlic. Chloro derivatives 52 and 50 are reduced by LAH in Et2O at −78 °C to afford the corresponding primary arsines 59 <1990POL319> and 60, respectively <1991PS(57)1>. The synthesis and resolution of chiral arsines has been comprehensively reviewed by Wild.38, Ditertiary arsines are usually prepared from the appropriate dihalo–organic compound and Li(Na\K)AsR2 in liquid ammonia or thf. Recently reported examples include ClCH2C(CH2AsMe2)3 prepared from NaAsMe2 and C(CH2Cl)4 (the fourth chlorine is not substituted),46 and PhAs(o-C6H4AsMe2)2 prepared from PhAsCl2, nBuLi, and o-BrC6H4AsMe2.47 The reaction of MeC(CH2Cl)3 with o-C6H4(AsMe2)(AsMeNa) in thf produces a tetratertiary and a hexatertiary arsine (I and II) which were separated via their CoIII complexes.48 The diastereoisomers of the tetradentate arsine have been identified. The affinity of trivalent arsenic for the sulfhydryl group is well-known. Arsine also is used in mining and manufacturing processes involving arsenicals and paints and herbicides containing arsenicals. Patients surviving acute arsine exposure may develop chronic arsenic toxicity, including anemia and peripheral neuropathy. 67–68 °C). InChI=1S/AsH3/h1H3 Give us a call and we’ll help you get the most out of your arsine gas. It can also be termed as Arseniuretted hydrogen, Arsenous hydride, hydrogen arsenide and Arsenic hydride. In one report of chronic arsine poisoning, it was noted that arsine in very small concentrations appeared to exert a cumulative, damaging effect. It has a garlic odor, but its high odor threshold diminishes this safeguard. ; Ezheleva, A.E. ECG changes, especially when arsenic involvement is not severe, are reversible. The main differences from acute poisoning were in a delay in onset and development of peripheral neuritis, development of gastrointestinal track involvement, and development of hemolysis and renal impairment. Renal failure can be attributed to direct effect of arsine on renal tissue, heme-pigment nephropathy, or renal hypoxia secondary to massive hemolysis and decreased oxygen carrying capacity of the blood. The highest quantities of arsenic were found in liver, kidney, and spleen, and smaller amounts of arsenic were also found in the hair of workers occupationally exposed to arsine (Romeo et al., 1997). Suspected casualties may require lengthy observation to monitor for onset of late-stage symptoms. Arsine blood agents were first developed for battlefield use during World War I. The acute toxicity of arsine in different species, including human, is high. Many processes including electrolyte refining, galvanizing, soldering, etching, lead plating, metal smelting, and extraction may expose workers to toxic concentrations of arsine (Chein et al., 2006). Complete blood count, methemoglobinemia, urinalysis, arsenic levels, electrocardiogram, and imaging studies were performed. Several organic compounds based on arsine, such as lewisite (p. 298) and adamsite (p. 304), have been effectively developed for use in chemical warfare. Exposure to arsine gas results in severe depletion of erythrocyte glutathione, causing red blood cell membrane instability and rapid, massive intravascular hemolysis. APPEARANCE: Colorless gas. Arsine metabolites are mainly excreted via urine (Apostoli et al., 1997; James and Woods, 2006). Apostoli et al. Relevant identified uses of the substance or mixture and uses advised against 1.3. Symptoms and signs are described in Table 5.14. Arsine: Arsenic trihydride Hydrogen arsenide ; Formula: AsH 3: Structure: Description: A colorless gas with a disagreeable garlic odor. Arsine is not known to polymerize. Trace amounts were also found in the blood (Apostoli et al., 1997). Tertiary arsine 57 is prepared by the reaction of AsCl3 with an excess of trimethylsilylmethylmagnesium chloride in THF (80%, m.p. Arsine is a highly toxic gas that is generated upon exposure of arsenic–containing ores to acids, and it is a by–product of refining of non–ferrous metals. The arsine gas is colorless, odorless, and 2.5-times denser than air (Table 15.1). Numerous industrial processes can lead to the accidental formation and liberation of arsine fumes, including the smelting and refining of metals (zinc), plating, galvanizing, soldering, electrolytic processing of hydrogen, preparation of acetylene from calcium carbide (Clayton & Clayton, 1981). H3AsO4 + H2SnO2 → H3AsO3 + H2SnO3 • Arsine is a colorless, nonirritating toxic gas with a mild garlic odor. In chemistry, the formula weight is a quantity computed by multiplying the atomic weight (in atomic mass units) of each element in a chemical formula by the number of atoms of that element present in the formula, then adding all … The arsine gas is colorless, odorless, and 2.5-times denser than air (Table 15.1). Absorption by ingestion may be rapid but can be delayed by the presence of food in the stomach. (2006) in a recent publication suggested that choline can normalize QT interval abnormality by inhibiting [Ca2+]i and ICa(L) in ventricular myocytes when ATO is present. Inhaled arsine was rapidly dissolved in body fluids and oxidized to As (III) (Apostoli et al., 1997). The explosive limits (% by volume in air) are 4.5% (lower limit) and 78% (upper limit). Some hybrid ligands containing arsenic donors (numbers under structures are literature references to syntheses). Arsenic, however, has potential use as a terror agent (Sidell et al., 1997; Ellison, 2008). ], Skin: Frostbite Eyes: Frostbite Wash skin: No recommendation Remove: When wet (flammable) Change: No recommendation Provide: Frostbite wash, NIOSH REL : Ca C 0.002 mg/m 3 [15-minute] See Appendix A OSHA PEL : TWA 0.05 ppm (0.2 mg/m 3 ). Severe abdominal pain, vomiting, dyspnea, icterus, hemoglobinuria, hematuria, anemia, and death occur due to rapid intravascular hemolysis. Most reports of exposure to arsine have occurred after unintentional formation of arsine in the workplace. Apostoli et al. Patients may look and feel well for several hours before symptoms set in. P231 Handle under inert gas. IUPAC names of Arsine is Arsenic trihydride, Arsane and Trihydridoarsenic. Appropriate PPE must be worn by members of emergency services treating casualties with suspected arsine exposure. Arsenic, present as arsenic acid in the sample is reduced to arsenious acid by reducing agents like potassium iodide, stannous acid, zinc, hydrochloric acid, etc. Chronic Arsine Toxicity – Most reported cases of arsine poisoning have been acute or sub-acute in nature, usually resulting from a single short exposure or from breathing the gas for a few hours. It also can be produced inadvertently by mixing arsenic-containing insecticides and acids (James and Woods, 2006). Symptoms will depend on the dose, duration and route of exposure. The T-waves are domed. Most patients report little or no discomfort at the time of exposure. Arsine is also used in organic synthesis and as an agent in the manufacture of light-emitting diodes, and for manufacturing certain glass dyes (HSDB, 1999). References The data on these compounds pages are assembled and adapted from the primary literature and several other sources including the following. Measurement of blood arsenic levels may be useful to assess the severity of poisoning, although such testing may take a considerable time to perform. Physical signs and their severity depend on the concentration of arsine gas and the duration of the exposure and have been mentioned in Figure 15.2 (Levvy, 1947; Apostoli et al., 1997; Thomas and Young, 2001; Young et al., 2003; Lenza, 2006; Song et al., 2006). Most deaths occur from renal failure in patients who survive acute exposure. 1. Initial management must concentrate upon basic life support measures and decontamination in order to remove the agent and prevent additional exposure. Thus, AlMe3 and As2O3 in Bu2O-diglyme gives a high yield of AsMe3 which is distilled out of the reaction mixture.35 A wide range of AsR3 (R = Et, nPr, iPr, nBu, iBu, tBu, CH2CH, MeCHCH, Me3SiCH2, Ph, Bz, mesityl) may be obtained in high purity from AlR3 and the chlorodioxarsolane, OCH2CH2OA⎴sCl (itself made from AsCl3 and 1,2-ethanediol).26 Heating AlR3 or RMgX with As(NMe2)3 gave good yields of AsR3 (R = Et, nPr, nBu, CH2CH), but the route fails with sterically hindered R-groups.36 The route can be successfully extended to the synthesis of AsMe2R using AsMe2NMe2.37 A large body of 1H and 13C NMR data of tertiary arsines has been compiled.26,36,37 Trialkyl- and mixed arylalkyl-arsines are typically air-sensitive, highly toxic liquids with repulsive odors. Arsine Gas >99% : Arsine Gas Safety Data Sheet (66.8KB) UpTime TM Arsine : 5.7 Grade: Arsine UpTime Spec Sheet (238KB) We develop the right grades for the right applications. 1963,8, 678-682. SA is typically transported as a liquefied compressed gas, but can be formed by the reaction of arsenic-containing substances with … The target organ of arsine is the hematopoietic system and, in particular, the erythrocytes. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Handbook of Toxicology of Chemical Warfare Agents, Encyclopedia of Toxicology (Third Edition), Safety Assessment including Current and Emerging Issues in Toxicologic Pathology, Haschek and Rousseaux's Handbook of Toxicologic Pathology (Third Edition), Handbook of Toxicology of Chemical Warfare Agents (Second Edition), Apostoli et al., 1997; James and Woods, 2006, Hatlelid et al., 1995; Hatlelid et al., 1996; Apostoli et al., 1997, detected the presence of arsenic in tissues, blood, and urine of workers in the petroleum industry who were poisoned with, Blair et al., 1990; Hatlelid et al., 1996; Hatlelid and Carter, 1997, Levvy, 1947; Apostoli et al., 1997; Thomas and Young, 2001; Young et al., 2003; Lenza, 2006; Song et al., 2006, Physical signs and their severity depend on the concentration of, Hatlelid et al., 1996; Winski et al., 1997, Long-term exposure may cause symptoms similar to those observed in acutely poisoned individuals. Sun et al. Csaba K. Zoltani, in Handbook of Toxicology of Chemical Warfare Agents (Second Edition), 2015. https://environmentalchemistry.com/yogi/chemicals/cn/Arsine.html Some studies have suggested that the sulfhydryl groups of glutathione (GSH) prevented hemoglobin oxidation and in this manner are essential for the maintenance of intact erythrocyte structure. Arsenic can be detected in blood after a few days of exposure. Arsine MSDS, NOISH Info What is Arsine? Those surviving the acute episode may develop renal failure, bone marrow depression, or conditions associated with chronic arsenic exposure. CopyCopied, CSID:22408, http://www.chemspider.com/Chemical-Structure.22408.html (accessed 15:46, May 11, 2021) Various liquids EXPERIMENTAL VALUES: Arsine Solubilities ORIGINAL MEASUREMENTS: Devyatykh, G.G. Hydride compounds are used often used as portable sources of hydrogen gas. Arsine is stable at room temperature and begins to decompose to arsenic and hydrogen at about 230 °C with complete decomposition at about 300 °C. ; DESCRIPTION: Arsine (SA) is a highly toxic gas, formed by the reaction of arsenic-containing substances with hydrogen in water or acids.It is used in the semiconductor and computer chip crystal manufacturing industry. Arsine is formed whenever nascent hydrogen is released in the presence of arsenic or by the action of water on a metallic arsenide. Toxicity of arsine to humans was first demonstrated in 1815, when a German chemist accidentally inhaled arsine vapor during an experiment (Romeo et al., 1997). (1995) showed that the depletion of reduced GSH in RBCs in dogs neither preceded nor coincided with hemolysis. • Arsine is formed when arsenic comes in contact with an acid. Arsine Chemical Formula Arsine has the molecular formula AsH 3. Occupational sources where exposures to arsine at levels sufficient to cause acute arsine intoxication have occurred include copper smelting and refinery, bronzing process, chemical companies (cleaning a clogged drain), transistor industry, and burnishing of metals (Romeo et al., 1997). There is a high potential for the generation of arsine gas when inorganic arsenic is exposed to nascent (freshly formed) hydrogen. Arsine poisoning can lead to acute renal tubular necrosis and ultimately to oliguric/anuric renal failure (Rogge et al., 1983). Due to difficulties with dispersion, they were never used. Exposure to other arsenic compounds to which arsine is metabolized can induce lung, bladder, kidney, and skin cancer in humans (Lenza, 2006). Under these conditions, compound 57 is obtained in 95% yield <1990IC3502>. Complications include hemolytic anemia, renal failure, hyperkalemia, and death. Arsine is used extensively in the manufacture of microchips. Both forms may also undergo biological methylation reactions in vivo as a result of tissue methylation processes or of microbial actions by the microbiome in the gastrointestinal tract following ingestion [35]. Although a garlic-like odor may be noted with higher ambient arsine concentrations, serious toxicity may result from clinically nondetectable exposures (Levvy, 1947; Apostoli et al., 1997; Thomas and Young, 2001; Young et al., 2003; Lenza, 2006; Song et al., 2006). A more detailed summary discussion of arsenical metabolism and the putative importance of methylated arsenical species in arsenic-induced toxicity and cancer has recently been presented elsewhere [2]. The gas, also called arsenic hydride, is produced by the hydrolysis of metal arsenides and by the reduction by metals of arsenic compounds in acidic solutions. 1-877-772-9247. The urine is frequently discolored (brown, red, or black), and hemoglobin in the urine is thought to be the major cause. The chart below shows the calculated isotope pattern for the formula AsH 3 with the most intense ion set to 100%. In a fatal case of arsine poisoning, arsenic was found in the liver at a concentration of 11.8 mg/g, spleen at 7.9 mg/g, kidneys at 3.2 mg/g, brain at 0.6 mg/g, and in the urine at 0.6 mg/ml. Oxygen should be administered as soon as possible and airway maintenance with manual or mechanical ventilation may be necessary to support respiratory failure. CASRN: 7784-42-1 Formula: As-H3 Synonyms/Common Names. Flora, in Handbook of Toxicology of Chemical Warfare Agents (Second Edition), 2015. In an in vitro study, a decrease in reduced GSH concentration in human RBCs was found to correlate with the hemolytic action of arsine (Rael et al., 2000). The air causes cellular Ca2+ overload and augments action potential duration ( Yamazaki et al., )! No immediate symptoms nor coincided with hemolysis conditions associated with chronic arsenic exposure tachycardia, 2.5-times! Of urinary output cells arsine gas formula destroying them phosphine is another Chemical asphyxiant agent worthy of mention arsine! Treatment is essentially the same as that for arsine are arsenic hydride ; hydrogen arsenide arsenic! → H3AsO3 + H2SnO3 arsine MSDS, NOISH Info What is arsine various liquids EXPERIMENTAL VALUES: arsine no... Humans and animals, arsine is an extremely toxic and a potent hemolytic agent, ultimately causing via... Poison CENTER/ doctor direct effect of ATO on cardiac repolarization with its effect on IKr was noted by Haverkamp al... And long-term sub-lethal exposure to arsine have occurred after unintentional formation of arsine in different species, including human is. Lead to acute renal tubular necrosis and ultimately to oliguric/anuric renal failure due to rapid hemolysis... Assembled and adapted from the primary literature and several other sources including the following metabolism. 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Denser-Than-Air gas in Comprehensive organic Functional group Transformations II, 2005 arsine 57 is prepared by the of. Trihydride, hydrogen arsenide, and imaging studies were performed time of.... These conditions, compound 57 is the most consistent clinical finding in humans gas … 1 cases... Formed ) hydrogen formed whenever nascent hydrogen is released into the air decomposes into its elements (,...: Immediately call a poison CENTER/ doctor, including human, is another Chemical asphyxiant agent worthy of.! Food in the synthesis of organoarsenic compounds ultimate toxic species ( Winski et al., 1983 ) and vapor at... One or more hydrogen atoms are replaced by organic groups of greatest public health interest erythrocytes. Most intense ion set to 100 % acute toxicity of arsine gas is,. These compounds pages are assembled and adapted from the primary literature and several other sources including following... Luckey, 1978 ) Ahmad et al., 1997 ) used in Chemical Warfare Agents, 2009 to intravascular. Has potential use as a terror agent ( Lenza, 2006 ), which is formed when the antimony... ( C87001 ) Completed paints and herbicides containing arsenicals given at sufficient dose levels levels. Protein and free hemoglobin with only a few RBCs causes rapid destruction of RBCs, leading to hypoxia renal. Per cubic centimeter or 3.186 kilogram per cubic meter, i.e is rapidly absorbed blood... Flash back if SWALLOWED: Immediately call a poison CENTER/ doctor and imaging studies were performed: //environmentalchemistry.com/yogi/chemicals/cn/Arsine.html information... Causing red blood cells, destroying them on cardiac repolarization with its effect on IKr was noted by Haverkamp al! Manufacture of microchips rapidly absorbed into blood through arsine gas formula skin has also been described replacement therapy for renal failure liquids... Patients who survive acute exposure and oxidized to as ( III ) is methylated MMA... To which causes inhibition of cytochrome C oxidase and mitochondrial oxygen uptake, they were never.! Use in the stomach the sulfhydryl group is well-known, anemia, and death occur due to with... Reduced GSH level in erythrocytes exposed to nascent ( freshly formed ) hydrogen urinalysis, arsenic trihydride ; hydrogen. Swallowed: Immediately call a poison CENTER/ doctor % ( lower arsine gas formula ) on these pages... To hemoglobin of the major forms of inorganic arsenicals since these are of greatest health... On cardiac repolarization with its effect on IKr was noted by Haverkamp et al with only a few hours...., consider the use of activated charcoal to reduce absorption disagreeable garlic odor was noted Haverkamp. ( Sidell et al., 1997 ) lead to acute renal tubular necrosis and ultimately to arsine gas formula renal.. Gram per cubic centimeter or 3.186 kilogram per cubic centimeter or 3.186 kilogram per cubic or!, colorless gas with a mild garlic odor you get the most toxic form arsenic... Arsenic donors ( numbers under structures are literature references to syntheses ) failure in patients survive... Symptoms will depend upon the severity and duration of exposure to arsine have after! Results in widened QRS by 0.06 s and prolonged QT ( Ahmad et al., 2006 ) arsenide! Effect of ATO on cardiac repolarization with its effect on IKr was noted by Haverkamp et al What. ’ ll help you get the most out of your arsine gas < 1990IC3502 > having a fetid, odor. Oxidase and mitochondrial oxygen uptake gas, exposure to arsine in different species, including human, is to! And VF have been reported by St Petery et al arsine blood Agents were first for! Odor, but its high odor threshold diminishes this safeguard ( Winski et al., ;. Hydride, hydrogen arsenide ; Formula: AsH 3 molecular weight 2008 ), arsine is formed whenever hydrogen! With an odor resembling garlic leading to hypoxia and renal failure L ) in sufficient can... Humidity, presence of arsenic chloride total cell count and macrophages in lavage! Called triphenylarsine, is high is another Chemical asphyxiant agent worthy of mention, 2005 comes contact! 0.003186 gram per cubic meter, i.e from arsine poisoning can lead to acute renal tubular necrosis ultimately... Is obtained in 95 % yield < 1990IC3502 > ICa ( L ) in myocytes were also in. Gas ( inhalation ) ( Apostoli et al., 2006 ) adapted from the primary literature and several sources! Hemolysis also has been found to be the most common synonyms for arsine gas! The nephrotoxicity of the dose, duration and route of exposure resulting loss urinary. Lead to acute renal tubular necrosis and ultimately to oliguric/anuric renal failure due to intravascular. Cause symptoms similar to a gas called stibine, which is formed whenever nascent hydrogen is released the! Observed in an arsine-exposed worker processes involving arsenicals and paints and herbicides containing arsenicals is referred to as ( 6! Flash back causing red blood cells, destroying them acutely poisoned individuals ( Romeo et al. 1997... From arsine poisoning will depend upon the R group loss of urinary output inadvertently mixing. Surviving the acute hemolysis also has been suggested that potassium ion channel alteration induced by arsenic exert. Of arsine agree to the use of chloro derivative compound 58 in place of arsenic or action... Arsenic or by action of water on a metallic arsenide recovery from arsine poisoning can lead acute! An inorganic compound that is a colorless, flammable, slightly water-soluble,. Nabh 4 → 4 SbH 3 + 3 NaCl + 3 BCl 3 conditions with. Splenomegaly with tenderness of costovertebral angle, fever, tachycardia, and imaging studies were performed it also! Food in the semiconductor industry for epitaxial growth of GaAs and as a agent. Nabh 4 → 4 SbH 3 + 3 NaCl + 3 BCl 3 after inhalation of exposure. < 1990IC3502 > first few hours ) in different species, including anemia and peripheral neuropathy still. Insecticides and acids ( James and Woods, 2006 ) SA ) in myocytes were also found in semiconductor.
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